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Players must crack number codes to make their way through the asylum. To do so, they place medicine cards onto asylum cards so that only certain numbers remain visible. Which numbers those must be is dictated by the adjacent asylum card.
The game includes three modes:
Freedom for All — Cooperative / Solitaire: All players work together (or alone) to escape the asylum.
Classic — Asymmetric / One-vs-Many: One person or group attempts to escape while another player takes the role of the guard and tries to hinder them.
Last One Out Closes the Door — Competitive (requires two copies): Two groups, each with their own copy of the game, play against each other.